Mindy is upset by Casey's decision to spend a year in Haiti, so she tags along with a premed student she's mentoring to a frat party, where she runs into her ex-boyfriend Tom. Meanwhile, Danny and Jeremy try to steal Morgan back from the midwives.
Before attending a medical conference in New Mexico, Mindy gets a message from her ex-boyfriend Josh, who's relocated to Santa Fe and wants to meet up with her. Meanwhile, Morgan assists Jeremy with an important presentation that could affect his future.
On a night on the town by herself, Mindy meets a handsome man—who just happens to be a prostitute—but the experience could pay off when she needs a date for Danny and Alex's dinner party, so she gives him a "Pretty Woman"-style makeover.
Mindy's new neighbor may turn out to be Josh's ex-girlfriend Heather—the woman who ruined her Christmas party—but not if Mindy can successfully sabotage her rental application. Meanwhile, Danny faces a moral dilemma when he helps out a childhood friend.
Mindy has a terrible birthday when her friends and co-workers accidentally mess up her party, but things go from bad to worse when she winds up in a fight with a new group of revelers she just happened to meet. Meanwhile, Danny and Jeremy both have their eye on Mindy's friend.
Mindy is offered the chance to deliver a medical report on the local TV news, and gets advice for appearing on camera from an unlikely source. Meanwhile, Beverly returns to the office as an administrative assistant, but is flummoxed by modern technology and youth culture.
Mindy's plans for a bunk bed for her goddaughter's sleepover go awry after Morgan and Danny's creation injures Gwen when it collapses. Meanwhile, Shauna and Betsy try to find out who's stealing the office's magazines, a search that yields some surprising discoveries.
Mindy's brother visits from college and shocks his sister with his plans to drop out of school and become a rap star. Meanwhile, Danny and Jeremy try to schmooze their landlord into lowering their rent for the office.
Mindy throws a Christmas party at her apartment for her colleagues, who finally get to meet Josh, but no one is more surprised than Mindy when she learns her new boyfriend's secret. Meanwhile, Jeremy doesn't find much cheer in giving out holiday bonuses.
Mindy cooks Thanksgiving dinner at Gwen's house, but is surprised that the guest list includes Dennis, her former blind date, who shows up with his new girlfriend. Meanwhile, Danny is all alone at the office; and Jeremy meets Betsy's unusual family at their holiday gathering.
Mindy asks Danny to be her new gynecologist, though neither one of them can admit their unwillingness to go through with an exam. Meanwhile, Jeremy has to retrieve something from Mindy's apartment, but needs Morgan and Betsy's help to break in to get it.
Shauna gets the staff into a hip nightclub, where Mindy connects with a lawyer for the New York Knicks. Meanwhile, Jeremy has his eye on a woman who happens to be engaged; and Morgan finds out how much money a bathroom attendant can make.
Ob-gyn Mindy Lahiri struggles to clean up the mess that is her personal life in the premiere of this sitcom, which begins with an unforgettable toast at her ex-boyfriend's wedding that leads to an embarrassing brush with the law.