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The DogTown team heads to a remote Indian community with no vet on a mission to spay and neuter as many dogs as possible. Back at the Best Friends Animal Sanctuary, a veterinarian aims to cure Rosa, a yellow lab mix, who keeps losing weight, and a DogTown trainer takes on Wilson's obsessive ditch digging to help the lab mix finally find a home.
A DogTown trainer resorts to an unusual training method to help one of DogTown's longtime residents, German Shepherd mix Mason. Training him to dance may increase Mason's chances at finding a family. DogTown staff head to Missouri to assist with a large scale puppy mill rescue, saving over 200 dogs.
A DogTown veterinarian's skills are tested with a severly ill, 8-week-old Catahoula mix puppy that may have a disease called "puppy strangles", which could lead to death. Trainers take on a 90 pound, out-of-control lab mix puppy who is still growing and a Shar Pei mix named Shorty who was traumatized during a brutal dogfight.
The DogTown staff launches a new program to turn shelter dogs into search and rescue animals. The team takes on difficult cases with Mocassin, a four-year-old hound mix in danger of losing the use of his back legs, and Cricket, a giant St. Bernard puppy, whose potentially debilitating disease has prevented her from finding a home.
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