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After her public breakdown, Catherine has issues to face at home and at work. At home, she finds out that Esme’s biological father has Leukemia and is in need of a marrow transplant from a blood relative causing Joshua and Reagan to tell Esme who her real parents are. At the Cube, Mahmoud reveals Catherine’s bipolar diagnosis to Owen who must decide if Catherine can continue working there; but Bickman steps in to argue that Mahmoud should be fired for breaking doctor/patient confidentiality. Will Catherine lose Esme and her job?
After experiencing hallucinations, Catherine ignores Dr. Hartramph’s advice to check into a hospital and have her medication rebalanced. Catherine needs to prepare for a TED Talk she is giving in Boston, but she may never get there as her symptoms intensify. With the botched surgery from 111 fresh on his mind, Bickman has his PTSD treated by Lina so he can get back into the operating room. Local mother, Mira, is brought into the Cube where they realize her sudden bravery is actually the absence of fear, a side effect of a rare syndrome known as Kluver-Bucy.
Bickman’s doorman Joey has bleeding in his brain from a brain aneurysm, and a second bleed is imminent, and likely to be fatal. During surgery, Bickman causes a complication that he has never experienced- massive bleeding. He has four minutes to repair the damage or it will result in permanent brain damage. Catherine confesses to Josh and Reagan that she told Will that Esme is her daughter. Hartramph tells Catherine that she did this to distract Will in order to hide her affair with Bickman. Catherine tells Will it’s over between them.
Lucia, 16, is brought into the Cube by her parents after many other doctors and hospitals have failed to diagnose the cause of her arm twitches, slurred speech and inability to finish her sentences.. After talking to Erica, Catherine learns that she went to camp upstate and she fears that Erica may have rabies. The test comes back positive and the disease has clearly spread to her brain. It is too late but her parents demand that Catherine find a cure. Also in the Cube, a man who was in a motorcycle accident weeks ago insists that he died in the accident and that he is now walking dead, in hell. Esme busses tables at Will’s restaurants and accidentally reveals to Will that the Hotel Mirabella is where Bickman lives, not where Catherine went for a conference.
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