Words I've been waiting months to hear: "What new kind of crazy is this?" That rant from Dr. Cox signifies that Scrubs is finally out of hibernation, and delirious lunacy once again reigns at Sacred Heart Hospital. (Wait until you see the mileage they get out of Pop Rocks.) Fans of irreverent TV comedy can rejoice, because Scrubs is joining a terrific two-hour sitcom block on NBC on Thursdays (Scrubs airs at 9 pm/ET).

Scrubs starts its sixth season with wacky slapstick confidence — don't miss the elaborate Blue Man Group gag — and an undercurrent of anxiety, as J.D., Turk, Carla and Cox all face parenthood issues with babies on the way. Does this mean they're growing up? Thankfully, not so you'd notice. It's still a blast. And while the competition (CSI, Grey's Anatomy) is brutal, at least Scrubs has mighty fine neighbors in My Name Is Earl, The Office and 30 Rock. Who says TV comedy is dead?

More good sitcom news, on cable: TBS, which specializes in repackaging modern classics like Everybody Loves Raymond and Sex and the City, comes up with a new winner of its own in My Boys (Tuesdays, 10 pm/ET). Imagine Carrie Bradshaw as a tomboy whose best pals are a bunch of goofy guys. PJ (the brash yet disarming Jordana Spiro) is a sportswriter, a girl in name only, who'd rather slug back brews over poker than lift a Cosmo at a club. Her gang is likably quirky company, but things get messy when PJ starts crushing on Bobby (Kyle Howard), a rival columnist unnerved by her aggressiveness: "Why is it that every time I talk to you I feel like the chick?"

My Boys can overdo the voiceover sports metaphors, but at least it's agreeable. Which is more than I can say for TBS' other new effort: 10 Items or Less (Mondays,11 pm/ET), a strained ensemble comedy set in a grocery store populated by losers. It's partially improvised, which comes off looking like they're having more fun than we are.

Saving the worst for last: ABC's Big Day (Tuesdays, 9 pm/ET) should be retitled "The Longest Day," as it spends an entire season showing us how many dreadfully unfunny complications can spoil a single wedding day. Frantic family members and planners fret over salads and seating charts, as tents collapse, rain falls, and the best man staggers around half-blind because the maid of honor — the bride's sister, whom he just bedded — swallowed his contacts. He's the lucky one, because he can just pretend this agonizing farce doesn't exist.