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Mark Sloan (Eric Dane), Grey's Anatomy
As if executive producer Shonda Rhimes hadn't put fans through enough anguish in the Seaon 8 with Lexie's death, the show returned with the somewhat shocking reveal — we say "somewhat" because Dane announced was leaving the series — that Mark eventually succumbed to his injuries and died after the plane crash survivors were rescued. His death was even more heartbreaking because we knew he'd finally be reunited with true love Lexie in the afterlife.