"It's been a job and a home and friendships for 50 years," longtime star Don Hastings told the AP at the final taping Wednesday. "I don't think it's hit me yet."
Daytime TV's longest-running soap opera, which follows the Hughes and Lowell families of Oakdale, Ill., was canceled in December after falling behind in the ratings in recent years. The hourlong show attracts an average of 2.4 million viewers per episode.
Helen Wagner, who starred on the series since its inception, died in May at 91.
After its debut on April 2, 1956, As the World Turns was the most-watched drama for 20 years. It was on the air Nov. 22, 1963, when Walter Cronkite cut in to announce the bulletin that President John F. Kennedy was assassinated.
As the World Turns, which has won four Daytime Emmys for outstanding drama series, is nominated for 13 awards at Sunday's 37th Annual Daytime Emmy Awards.
The show's end follow the demise of CBS' Guiding Light, which went off the air in September after running 72 years on radio and television. ABC's General Hospital will become TV's longest-running soap; it debuted in April 1963.
Are you sad As the World Turns is going off the air?