Scott was known for incorporating catchphrases into his reporting that often became part of the sports lexicon (and were parodied on SaturdayNight Live), including "Boo-yah!"
Born in Chicago, Scott grew up in North Carolina and earned a degree in speech communication from the University of North Carolina, where he began his on-air career as a student. Upon graduating, he worked as a reporter for local stations in the Carolinas and Florida before joining ESPN in 1993 as the host of SportsNight on ESPN2.
During his career at ESPN, Scott covered games across a variety of sports and interviewed stars from the sports world and beyond, including Tiger Woods, Michael Jordan, Bill Clinton and Barack Obama.
Scott was first diagnosed with cancer in 2007 and battled the disease on and off until his death this week.
At the ESPY Awards last July, Scott received the Jimmy V Award for Perseverance, and told the audience: "When you die, it does not mean that you lose to cancer. You beat cancer by how you live, why you live and in the manner in which you live."
He is survived by two daughters, ages 19 and 15.
Watch ESPN's tribute to Scott below: