The actress, 27, and boyfriend James Hesketh wed at City Hall in New York City on Friday before her father and his fiancée, Kayte Walsh, TMZ reports. The couple, who started dating last year, got engaged less than a month ago.
An email to Spencer's rep was not immediately returned.
Kelsey and Camille finalized their divorce Thursday, freeing the actor to marry Walsh, who will be his fourth wife. Kelsey has said he plans to wed Walsh this month.
Spencer is the Frasier's star only daughter with his first wife, dance instructor Doreen Alderman. He also has an 18-year-old daughter, Greer, with hair and makeup stylist Barrie Buckner, and a 10-year-old daughter, Mason, and a 6-year-old son, Jude, with Camille.