Mark Feuerstein Mark Feuerstein

Mark Feuerstein says his Royal Pains' is going to face his greatest medical challenge yet.

"In every episode he saves every life, but in this season ... particularly with Jack O'Malley (Tom Cavanagh), it's never been a greater medical challenge," he tells "When that comes to a head, it takes the show into an epic and darker dimension than it's ever gone."

5 teases from Royal Pains' Return: A new love triangle and fallout from Divya's big blunder

Along with facing medical challenges, Feuerstein says Hank will question his trust in two people close to him: Divya (Reshma Shetty) and his brother Evan (Paulo Costanzo). In the interview below, Feuerstein discusses how Hank's relationships with the two have been compromised and teases that his upcoming directorial debut includes a hip-hop video.

Royal Pains airs Wednesdays at 10/9c on USA.