O'Donnell, 47, has signed a domestic TV syndication deal that reteams her with former Warner Bros. TV distribution executives Scott Carlin and Dick Robertson, according to Showbiz411. Both Carlin and Robertson helped launch her first chat fest, The Rosie O'Donnell Show, in 1996.
The duo hopes to premiere O'Donnell's new project in fall of 2011, when The Oprah Winfrey Show exits network daytime TV, Showbiz411 reports.
The Rosie O'Donnell Show ran for six years. It won the Emmy for best talk show five years in a row and the award for outstanding talk show host six years in a row. O'Donnell served as a moderator on The View from 2006 to 2007.
In 2008, O'Donnell unsuccessfully tried to launch a variety show on NBC, Rosie Live, but the first episode attracted just 5.25 million viewers.