O'Reilly, who saw the opportunity to get things "on the record," questioned Obama on the IRS, health care and the 2012 Benghazi attack.
The Fox News host went after Obama's reaction to the attack in Libya, implying the President didn't initially refer to it as a "terrorist attack" for political gain.
"Your detractors believe that you did not tell the world it was a terror attack because your campaign didn't want that out," O'Reilly said. "That's what they believe."
"And they believe it because folks like you are telling them that," Obama retorted.
And that wasn't the only time Obama went after Fox News. Watch the full interview below to see all the contentious interaction.
What did you think of the interview?