The Game of Thrones star was hand-picked by editor-in-chief David Granger, who tells WWD: "There's an effortless power he conveys on-screen that is inimitable. ... We knew it would be a great cover with one of the great actors of the moment."
On the cover, Dinklage, 44, dons a custom-made Giorgio Armani suit. The issue also includes a lengthy interview with the actor about his life off-screen.
Game of Thrones kicks off its fourth season on April 6.