In the comedy, two female friends, Nicole (Andrea Anders), who seemingly has the perfect life, and Jen, who can't seem to get it together, can't live without each other. Hopkins will play the husband of Nicole. As previously announced, Rachel Dratch and Danny Comden will also star.
Lady Friends is in second position to Cougar Town, which means if ABC renews the flagging comedy, Hopkins will stay in the cul-de-sac crew. In the meantime, Hopkins will soon guest-star on In Plain Sight.
Cougar Town creator Bill Lawrence teased the news earlier Tuesday. "Letting my cast do pilots in 2nd position," he tweeted. "Hoping they get parts, then have to be replaced (like Damon Wayans Jr. Happy Endings/New Girl... I'm still betting we will survive, and that pilot will be screwed. But I'm an optimistic guy."
The New Adventures of Old Christine' Lizer will write and executive-produce.