Michelle Nicastro in Who's the Boss? Michelle Nicastro in Who's the Boss?

Michelle Nicastro, an actress and singer best known for introducing the titular characters in When Harry Met Sally..., has died. She was 50.

Nicastro died Nov. 4 after a 10-year battle with cancer, according to The Hollywood Reporter.

A Washington, D.C., native, Nicastro got her start in theater, originating the roles of Ariadne in the 1983 Broadway musical Merlin and Eponine in the original 1988 Los Angeles production of Les Misérables, respectively. She won the DramaLogue Critics Award and the Robby Award for her work in Les Misérables.

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After making her film debut in 1984's Body Rock

, Nicastro co-starred in 1989's When Harry Met Sally... as Amanda Reese, Harry's college sweetheart who introduces him to her friend, Sally. Nicastro also voiced Princess Odette in The Swan Princess and its two sequels.On television, Nicastro starred on the NBC soap opera Santa Barbara for two years and won ACE and BMI awards for an original song she co-wrote and performed on It's Garry Shandling's Show. She also guest-starred on such series as Airwolf, Charles in Charge, Who's the Boss?, Knight Rider, Murder, She Wrote, Full House, Beverly Hills, 90210, Wings and Coach.Nicastro released four albums, including Toonful and Toonful Too, which featured songs from animated musicals.Nicastro is survived by her husband of 24 years, Event producer Steve Stark; daughters Callie and Cady; and sisters Beth Ann and Kristin.