"We all miss Lisa very much," the 52-year-old actor told reporters at the fall TV previews Saturday, according to TVLine.
Edelstein, who played House's boss and love interest, Cuddy, left the Fox medical drama last month after seven seasons. Her departure followed an explosive — and critically panned — season finale which saw House (Laurie) drive into Cuddy's house months after their break-up. Edelstein's exit leaves the show without a love interest for the title character and seemingly little hope of resolution for "Huddy," as fans dubbed the will-they-or-won't-they couple.
While promoting his new PBS special, Great Performances: Hugh Laurie: Let Them Talk — A Celebration of New Orleans Blues, Laurie also confirmed a report that his character would be behind bars when House returns. "I am a prisoner," he said. "I don't know [how long I'll be there]. They keep me in the dark. It's probably better that way."
The new season of House premieres on Monday, Oct. 3 at 9/8c on Fox. Edelstein will next appear on The Good Wife in a multi-episode arc.