Larry King Now will premiere on Monday on the online video site and will become available for viewing in the early evening, Monday through Thursday. Digital network Ora.TV will also run the series.
"I have always been driven to innovate, from my time on radio, to the first call-in show on national television, to being an early adopter of online columns and Twitter," King said. "I am thrilled about our partnership with Hulu. I love being able to interact directly with audiences, and digital TV allows me to do this in new and powerful ways."
King, 78, previously hosted Larry King Live, which CNN canceled in 2010 after 25 years.