Depp, 50, and Heard, 27, met on the set of The Rum Diary. They later confirmed their relationship in June 2012. The two will appear together again on screen in London Fields, out later this year.
Depp was previously with longtime girlfriend Vanessa Paradis with whom he has two kids, Lily-Rose, 14, and Jack, 11. Heard dated Tasya van Ree for three years, coming out as bisexual in 2010.