The cast for The Anatomy of Hope, an HBO medical-drama pilot from J.J. Abrams ( Lost, Alias) that explores cancer battles from the patients' point of view, includes Chris Messina ( Six Feet Under) and Simon Callow ( The Phantom of the Opera) as oncologists, the Hollywood Reporter reports. Also on board, playing cancer patients past, present and potential, are John Ortiz ( Miami Vice), Valerie Pettiford ( Half & Half), Matt Craven ( Disturbia) and Daryl Edwards ( Rent).