Clayburgh passed away at her home in Lakeville, Conn. after a 21-year battle with chronic leukemia, her husband told the newspaper.
Clayburgh got her start in theater, appearing in shows including the original Broadway run of Pippin, before moving to the big screen. She is best known for her starring roles in An Unmarried Woman and Starting Over, both of which earned her Academy Award nominations for best actress.
Clayburgh was also nominated for two Emmy awards, for the TV movie Hustling and a guest appearance on Nip/Tuck. Her most memorable small screen roles include playing Ally McBeal's mother, and Darling family matriarch on the 2007 drama Dirty Sexy Money.
Clayburgh is survived by her husband, playwright David Rabe, her daughter, Broadway actress Lily Rabe, her son, Michael, and her stepson, Jason.