"Jesse checked himself into a treatment facility to deal with personal issues," his rep said in a statement to the magazine. "He realized that this time was crucial to help himself, help his family and help save his marriage."
It is unknown what James, 40, is seeking treament for or where the facility is located.
Since In Touch first published a cover story about James' reported extramarital affair with Michelle "Bombshell" McGee, three other women have come forward claiming to have had affairs with the former Monster Garage star. Bullock, who won an Oscar earlier this month, has since abruptly pulled out of two European premieres for The Blind Side.
James has three children from a previous marriage and has been married to Bullock since 2005.
E-mails to James' rep were not immediately returned.