This year's 15 contestants have collectively accumulated 21 Emmys, eight Peabodys, four Pulitzer Prizes and a Grammy Award, in addition to serving under three White House administrations.
Each player will walk away with at least $10,000 for the charity of their choice, with the winner of each game set to receive a minimum of $50,000 for their cause.
Jeopardy! Power Players Week will tape in front of an audience at DAR Constitution Hall in Washington, D.C., on April 21, and air May 14-18.
Check out the full list of power players:
Kareem Abdul-Jabbar, NBA's all-time leading scorer
Lewis Black, stand-up comedian
Anderson Cooper, host of Anderson Cooper 360 and Anderson
David Faber, host of CNBC's The Faber Report and Squawk on the Street
Thomas L. Friedman, The New York Times
Robert Gibbs, Former White House Press Secretary
Katty Kay, BBC World News America anchor
Chris Matthews, host of MSNBC's Hardball and NBC's The Chris Matthews Show
Kelly O'Donnell, NBC News correspondent
Lizzie O'Leary, CNN correspondent
Dr. Mehmet Oz, host of The Dr. Oz Show
Clarence Page, Chicago Tribune
Dana Perino, co-host of Fox News Channel's The Five
Chuck Todd, NBC News correspondent
Chris Wallace, Fox News Sunday anchor
Who do you think will come out on top?