"We have decided to end our marriage," the couple said in a joint statement. "This was a very difficult decision. We have come to an amicable conclusion on all matters. It is a painful time for all involved, and we appreciate the respect of our privacy at this time."
Lopez, 41, and Anthony, 42, married in 2004. The American Idol judge gave birth to their twins, Max and Emme, in 2008.
Anthony recently became a series regular on HawthoRNe, while J.Lo is still on the fence about whether she'll return to Fox's Idol. In the spring they announced they were developing the talent competition show Q'Viva, which features Lopez and Anthony searching Latin America to discover new musical talent. There's been no word whether their split will affect the series.