Cartoon Marriage is about a New York cartooning couple, told through each of their perspectives. It's based on the eponymous book by Michael Maslin and Liza Donnelly.
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Garner will executive-produce and Less Than Perfect creator Terri Minsky will write.
This is the second project that Garner's production company, Vandalia Film, has signed on for with ABC. The company is also adapting the book The Greeks Shall Inherit the Earth as a half-hour comedy.