"The world of music will be a poorer place without him, but he lives on in his music and forever in our hearts," his family said on his website.
Bruce played in various groups before joining the Graham Bond Organization is 1962 and then later joining John Mayall's Blues Breakers. In that band, Bruce met Eric Clapton, which led to the formation of Cream.
Bruce, Clapton and drummer Ginger Baker formed the group in 1966 and they produced hits including "Sunshine of Your Love," "White Room," and "Crossroads," among others.
Cream eventually disbanded in 1968, and Bruce went to record solo albums and front bands. He had just released a solo album, Silver Rails, in March.
Cream briefly reunited in 1993 for the band's induction into the Rock and Roll Hall of Fame.