T.R. Knight and Katherine Heigl, <EM>Grey's Anatomy</EM> T.R. Knight and Katherine Heigl, Grey's Anatomy

Question: I was hoping that Izzie and George hooking up would be one of the false plot twists in your Grey's Anatomy tease last month (Ask Ausiello 2/21). But I just saw the preview for tomorrow's episode and I'm freaking out. Please tell me it's some kind of mistake.

Answer: Let me just say this: After tomorrow's Grey's airs, you'll know which one of the six plot twists is real. Here they are again in case you're too lazy to click on the link above.

• After breaking things off with Cristina, Burke will transfer to another hospital.
• Callie will reveal she's pregnant.
• Izzie and George will hook up.
• Izzie will be reunited with her daughter, and it's someone we've already seen on the show.
• Addison will be diagnosed with a life-threatening illness.
• Derek and Meredith's relationship will hit a roadblock when one of her exes shows up on her doorstep with one thing on his mind.