The two casts collided at the taping for the upcoming NBC special honoring acclaimed sitcom director James Burrows.
"Ummmm NIGHT MADE," Cuoco captioned the photo. "Can't breathe #friends meets #bbt @bigbangtheory_cbs I died and went to heaven."
The special is the first time the Friends have been together onscreen since the show ended in 2004. Matthew Perry couldn't make it, as he is starring in a play in London, but Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer were there to pay tribute to Burrows.
Burrows directed the Friends pilot -- one of 15 episodes he helmed for the show -- and more than a thousand other episodes of television, including Cheers, Frasier, Taxi and Will & Grace. Stars from all those shows and more were at the taping.
Must See TV: A Tribute to James Burrows airs Sunday, Feb. 21 at 9/8c on NBC.