Ellen Pompeo, Sandra Oh Ellen Pompeo, Sandra Oh

Remember when Cristina and Meredith became each other's person?

Throughout 10 seasons of Grey's Anatomy, Meredith (Ellen Pompeo) and Cristina (Sandra Oh) have developed a relationship that goes beyond BFF status. It's the type of relationship where you cut someone out of a wedding dress, you're by someone's bedside when they wake up after dying, and you help someone deal with the loss of their eyebrows — or worse, their sister (Chyler Leigh).

Grey's Anatomy Gallery: The cast says farewell to Sandra Oh!

This, of course, all makes saying goodbye to Oh that much more difficult: No more twisted sisters! Look back on their best moments from the show below:

What are your favorite Cristina and Meredith moments?

Grey's Anatomy airs Thursdays at 9/8c on ABC.