Patrick Dempsey and Eric Dane on Grey's Anatomy by ABC/Ron Tom Patrick Dempsey and Eric Dane on Grey's Anatomy by ABC/Ron Tom

Seattle Grace newcomer Dr. Hahn has dubbed the reconciled friends "Pretty and Prettier," but Grey's Anatomy's Eric Dane tells TV Guide the buddies may be headed for another breakup. "[Mark and Derek] will continue to repair their friendship, but I wouldn't be surprised if it was torn apart again," he says. "That's what we're really good at doing on Grey's Anatomy - building relationships, breaking them up and putting them back together again."

Dane spoke to TV Guide Thursday at Project Angel Food's Divine Design Gala at the Beverly Hilton Hotel, where he presented his actress-wife Rebecca Gayheart Dane ( Vanished) with the Divine Design Woman of Style Award.

"They say that behind every great woman of style is the lucky guy who zips up her dress," Dane said at the podium. "I wrote that." Joining him on stage, Gayheart Dane replied, "Thank you, babe. I'm blushing after that." - Reporting by Bekah Wright