Ellen Pompeo Ellen Pompeo

"I just don't know if my marriage can survive this," Meredith (Ellen Pompeo) wonders in the first teaser for Grey's Anatomy's 11th season.

Scoop on Grey's Anatomy and more returning fall shows

After informing Derek (Patrick Dempsey) that she isn't following him to Washington, D.C., the couple seems to be stuck at an impasse. April (Sarah Drew) even tells Jackson (Jesse Williams) that Derek is "dying inside" as the couple takes on this new hurdle — all without the support of Meredith's person, Cristina.

Grey's Anatomy returns Thursday, Sept. 25 at 8/7c on ABC. Watch the teaser below.