Grey's Anatomy will look a lot different when it returns next week — and we don't just mean because of the fire that nearly burned Grey Sloan Memorial down in the Season 13 finale.

A couple of familiar faces are leaving and returning — including a new face as an old face (you'll see what we mean). How will this affect Mer (Ellen Pompeo) & Co? Here's what you can expect from Season 14.

Edwards (Jerrika Hinton) is out: Edwards made her final appearance in the Season 13 finale, in which she quit after surviving the hospital fire. Hinton left Grey's, which she joined in Season 9, to star in Alan Ball's new HBO series Here, Now. Her exit had been in the works for a while: She almost left after the 12th season, when she was cast in Shonda Rhimes' comedy pilot Toast, which ultimately was not ordered to series.

Minnick (Marika Dominczyk) is also out: After getting fired by Bailey (Chandra Wilson) in the finale, Minnick, who romanced Arizona (Jessica Capshaw) and was, uh, let's say the opposite of a fan favorite, is also not returning.

Murphy (Tessa Ferrer) is out too: Minnick's departure doesn't mean Arizona will rekindle things with Murphy though, because her one-time flame is also bidding adieu. Ferrer, who originally exited after Season 10, returned to the show last year after Murphy was rehired at Grey Sloan.

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Megan Hunt will look a wee bit different: Not just because she's been missing and presumed dead for 10 years. Bridget Regan was unable to reprise her role as Megan due to scheduling conflicts with The Last Ship and will be replaced by Abigail Spencer. No word on how long Owen's (Kevin McKidd) sis is sticking around, but Spencer starts production on Season 2 of Timeless in November, so you can probably expect a lotta Megan in the first couple of episodes.

Sister act 2: There's yet another family affair in the offing. Italian actress Stefania Spampinato joins the show as Carina DeLuca, Andrew's (Giacomo Gianniotti), whose arrival at Grey Sloan will be a thorn in her bro's side. Why? She's got a "controversial" profession in the medical field.

Teddy's back: Kim Raver, who left in Season 8, will return as Dr. Teddy Altman for a guest arc. After identifying Megan overseas, Teddy accompanies Megan back to Seattle and reunites with her old pal Owen. Plus, he probably needs a close confidant now that Megan is suddenly back in his life.

"His sister's been gone [and] that's just something he wakes up and thinks about all day, every day," Gianniotti told TV Guide about Owen's reaction. "So to have her come back is so revitalizing for his character. It's so many emotions."

Kim Raver, Kevin McKidd, Martin Henderson and Ellen Pompeo, Grey's AnatomyKim Raver, Kevin McKidd, Martin Henderson and Ellen Pompeo, Grey's Anatomy

Meredith is the other woman again: Meredith's boyfriend's old flame abruptly enters the picture out of nowhere. Sound familiar? Megan, of course, is not only Owen's sister but Nathan's (Martin Henderson) old flame. And with Meredith encouraging him to reconnect with Megan, Mer and Nathan might be done for now. "They both had a similar experience [losing their partners], but now this experience for Nathan is not even possible for her. Derek is not coming back," executive producer and star Debbie Allen told us. "She will be re-examining and figuring out what's important in her life and how she will move on emotionally."

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Jo (Camilla Luddington) needs a new person: With her BFF Edwards gone, Jo is pretty lonely and is desperately seeking a new pal. "I think Jo is going to try and attempt to lean on Ben (Jason George) a bit this season," Luddington said. "Is it successful? I don't know. I think she's trying to pull anyone close to her and that's another resident. ... As for other women, I don't know yet. That'll be interesting." Don't get too attached to Ben, girl.

Bye, Ben: Ben is not long for Grey Sloan. No, he's not biting it, but Jason George will be moving over to the firefighter spin-off set to launch midseason. Don't fret about Ben and Bailey though. The couple will still be together; you'll just be seeing less of him on Grey's. "there will definitely be crossovers between Grey's and the spin-off show," George told TVLine. "I think kind of along the lines of what happened with Private Practice and Grey's. Bailey can come home and fall into bed, and there's Ben, and they can talk about their day. Or Ben comes home from fighting fires all day and falls into bed, and there's Bailey."

Grey's Anatomy premieres Thursday, Sept. 28 at 8/7c with a two-hour episode on ABC.