The sad day when April Kepner (Sarah Drew) and Arizona Robbins (Jessica Capshaw) leave Grey's Anatomy is finally upon us.

The two favorite characters' final episode will be the Seaosn 14 finale, which airs Thursday, May 17 on ABC. The big episode will center on Alex (Justin Chambers) and Jo's (Camilla Luddington) wedding, where all of their family and friends will see them finally walk down the aisle.

As many Grey's fans know, weddings are seldom happy events on the hospital drama. Cristina (Sandra Oh) bailed on hers before she could trade vows with Burke (Isaiah Washington). April also split on her wedding to Matthew (Justin Bruening) before the nuptials were completed. Adele (Loretta Devine) died during Bailey's and Alex's wedding was capped off with George (T.R. Knight) leaving the show (though his death officially occurred in the next episode).

Grey's Anatomy Sneak Peek: Jo and Alex's Big Day Hits a Snag

Why are we bringing up these sad memories for what is supposed to be a happy occasion? Learning from history, we know that as an even-numbered finale, Grey's shouldn't rip hearts out this year, but it's important you be prepared for potential heartbreak. At the very least, the wedding will be the last time we see April or Arizona for a long while, so bring tissues.

The finale airs Thursday, May 18 at 8/7c on ABC. Check it out live on TV or on ABC.com

Grey's Anatomy returns for a history Season 15 this fall on ABC.

Jesse Williams and Sarah Drew, <em>Grey's Anatomy</em>Jesse Williams and Sarah Drew, Grey's Anatomy