Neve Campbell

Neve Campbell is coming to Seattle Grace!

The Scream alum will check into Grey's Anatomy starting Thursday, Dec. 6, and TVGuide.com has a first look at her arrival. Campbell, who co-starred alongside Patrick Dempsey in Scream 3, will play his sister on Grey's. But which sister?

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We've already met Derek's sisters Nancy (Embeth Davitz) and Amelia (Caterina Scorsone), while another sister named Kathleen, a psychiatrist, has been mentioned. But TVGuide.com has learned Campbell is actually playing his fourth sister, Liz "Lizzie" Shepherd.

Her arrival comes as Derek has turned to teaching after his hand was mangled in last season's plane crash. Could Lizzie be arriving to help? We know Meredith (Ellen Pompeo) will enlist Heather (Tina Majorino) to go above and beyond to help fix Derek's hand and they are together in the photo below:

Grey's Anatomy airs Thursdays at 9/8c on ABC.