Jay-Z, John Legend and Lady Gaga went home with three trophies each. Eminem, who led with 10 nominations, only captured two: rap solo performance for "Not Afraid" and rap album for Recovery — 2010's best-selling album.
Jazz artist Esperanza Spalding pulled off the night's biggest upset, earning best new artist honors over Justin Bieber, Drake, Florence + The Machine and Mumford & Sons. She is the first jazz artist to win the award.
Train won the first award on the prime-time telecast, taking pop duo/group vocal for their live version of "Hey Soul Sister."
"Thanks, Justin Bieber, for not being a duo or group," frontman Pat Monahan said.
Other winners included Usher, Jeff Beck, The Black Keys, Bruno Mars, Rihanna, Miranda Lambert, Cee Lo Green, and Danger Mouse
Pop Duo/Group Vocal: "Hey Soul Sister" (Live), TrainPop Vocal Album: The Fame Monster, Lady Gaga Rock Album: The Resistance, Muse Rap Album: Recovery, Eminem Female Country Vocal: "The House That Built Me," Miranda LambertCountry Album: Need You Now, Lady Antebellum