"Happy to announce that today we are the proud parents of our second daughter, Frankie Barrymore Kopelman," Barrymore and her husband Will Kopelman said in a statement. "Olive has a new little sister, and everyone is healthy and happy!"
This is the second child for Barrymore, 39, and Kopelman, 36, who married in 2012. Their other daughter, Olive, is 19 months old.
Barrymore next stars in the comedy Blended, which hits theaters next month.