Drea de Matteo was one of many who lost her home in Thursday's building explosion in downtown Manhattan.

"A hole where my N.Y.C. home of 22 years once stood," The Sopranos star shared on Instagram, along with a photo of the wreckage.

A hole where my NYC home of the last 22 years once stood... RIP 123 2nd Avenue

A photo posted by Drea De Matteo (@dreadematteo) on

21 epic celebrity slimes

"NYC's finest trying to put out the flames to mine n many other apartments," de Matteo wrote in another post, sending prayers "for those that are hurt."

NYC's finest trying to put out the flames to mine n many others apartments Speechless... for those that are hurt

A photo posted by Drea De Matteo (@dreadematteo) on

According to CBS, 19 people were injured in the explosion, which left four in critical condition. Five of the injured were fire fighters.

"Our thoughts and prayers are with every one of them and their families. Of course, we are praying that no other individuals are injured and there are no fatalities," Mayor Bill de Blasio said.