Amphlett suffered from breast cancer and multiple sclerosis in recent years.
Born Christine Joy Amphlett in Geelong, Victoria, Australia, Amphlett formed Divinyls in the early 1980s in Sydney with Mark McEntee and Jeremy Paul. The band, which underwent several lineup changes before breaking up in 1996, is best-known for its 1991 hit "I Touch Myself." In 2006, Divinyls were inducted in the ARIA Hall of Fame and announced a new album and tour.
Amphlett also dabbled in acting. She had a supporting role in the 1982 movie Monkey Grip and starred alongside Russell Crowe in the stage musical Blood Brothers in Australia in 1988. She also played Judy Garland in the original touring production of The Boy from Oz.
Crowe tweeted a message of remembrance Monday. "Dear Chrissie, The last time I saw you was in the Botanic Gardens, loving life and reciting verse," he wrote. "That's how I'll remember you, your boy, R."
In 1999, Amphlett married drummer Charley Drayton. She announced that she had been diagnosed with multiple sclerosis in 2007 and revealed that she had breast cancer in 2010. In 2011, Amphlett said she had beaten breast cancer.
She is survived by Drayton.