Theron will make her second appearance as host on May 10 with musical guest The Black Keys. The following week, Samberg will return to the sketch series for its finale with St. Vincent, who makes her musical guest debut.
Theron and Samberg join previously announced host Andrew Garfield, who will make his debut on May 3 with five-time musical guest Coldplay.
Behind on SNL? Catch up on episodes here and see what shows are Samberg's favorites below.