"Reach for the stars everyone. dogspeed cadre. c out," Sheen tweeted on Friday.
Sheen joined the social media site in March 2011, just weeks after being fired from Two and a Half Men. His first tweet featured one of his headline-making phrases, "#winning." He then became Twitter's most talked about actor for that year. His catchphrase #tigerblood was listed as the second most talked about hashtag of the year.
Sheen, who amassed nearly 8 million followings since he joined Twitter, most recently used his account to promote and live-tweet his new FX comedy, Anger Management.
Will you miss Sheen's tweets?