Spiritual guru Oprah Winfrey has signed a new deal to host The Oprah Winfrey Show through the 2005-06 season, at which point she'll bow out of the talk show arena for good, according to The Hollywood Reporter. The timing of Winfrey's swan song is significant: The 2005-06 season marks the 20th anniversary of The Oprah Winfrey Show's debut in national syndication.