Amy Madigan by Jordin Althaus/ WireImage.com
Now that she has screwed Mer's head (mostly) on straight on Grey's Anatomy, Amy Madigan is teaming up with longtime gal pal Holly Hunter on the third Season 2 episode of TNT's Saving Grace. "She was kinda brilliant," Hunter says of Madigan's guest-star turn as the wife of a murdered cop. "She made me really step up to the plate."

Hunter and Madigan go back a ways, having previously costarred in the TV-movie Roe vs. Wade (1989). To reunite on Grace, Hunter says, "was such a privilege because she's been a friend of mine for years. And to play opposite her... she was so electrifying!" - Matt Mitovich, with reporting by Erin Fox