Lori Loughlin, In Case of Emergency
Remember when Lori Loughlin made Uncle Jesse utter "Have mercy!" on the long-running Full House? Well, 12 years later, in the new ABC comedy In Case of Emergency (Wednesdays at 9:30 pm/ET, premiering tonight), she's still making men weak in the knees. Playing sweet-but-serious Dr. Joanna Lupone, Loughlin finds herself with a stethoscope around her neck — much like former TV flame John Stamos, who's tending to patients on ER these days — and David Arquette's disheveled and persistent character on her heels. TVGuide.com got the scoop about In Case's hilarious cast, the idea of reuniting with Stamos, her Summerland blues and more.

TVGuide.com: Are you excited for the debut of In Case of Emergency?
Lori Loughlin: Oh, I'm so excited. It's so great to finally have an airdate. It's such a zany, screwball comedy.

TVGuide.com: I watched the first couple of episodes, and I liked the premise — these friends from high school are at a weird point in their lives and are unsure of who they've become, and we're watching them reconnect through tragedy.
Loughlin: Isn't it so true how out of so much tragedy [comes] comedy? There could be something tragic happening, and you just make jokes because you need that levity in life.

TVGuide.com: Your character seems to be the most levelheaded one!
Loughlin: She is, until David Arquette's character [Jason] just cracks her. [Laughs] He just breaks her down!

TVGuide.com: But your character didn't go to high school with the rest of them, right?
Loughlin: No, she did not. They want to concentrate on that relationship of the four friends from high school, but they also want to be able to have an avenue out, to be able to go to another place. And hospitals are always so great, because whether it's a drama or a comedy, so much can happen at a hospital.

TVGuide.com: It's a really good cast. Jonathan Silverman (The Single Guy) is great at making Harry awkwardly funny. He's afraid of everything, but he seems to be the glue that holds the group together.
Loughlin: You're absolutely right, he definitely is, and they all end up living at his house. He's so fantastic in that role.

TVGuide.com: And Sherman, played by Greg Germann (Ally McBeal) is just a mess. He's this "diet doctor" who has all these frozen meals and self-help books with his face on them, but meanwhile he needs a lot of help.
Loughlin: Oh, Greg's hilarious. There are many different stories to be told, but I think the thing that's very important — and what I've always thought was key for a successful show — is the chemistry among the cast, and the three guys on the show have such a great connection. You can have great writing, which we do, but you need actors who click, and we all really do.

TVGuide.com: How do you like playing a doctor?
Loughlin: I love it. I love being the one who's intelligent and levelheaded and in control. I love the fact that it's all a facade and a journey and at the end of the day, the doctors whom we need and put all our trust in are just human beings.

TVGuide.com: Are we going to see Joanna get together at some point with Jason, even though she's engaged?
Loughlin: He definitely wears her down, he's so relentless. He becomes a candy striper at the hospital, so he's under her feet all the time, and she cannot get rid of him. But she then starts to realize that her fiancé looks like the perfect guy on paper and fits into her so-called perfect plan and perfect life, but maybe she doesn't have it all together, either. Maybe she doesn't have the answers herself. She took the path that she thought was right, and she did everything by the book. But at the end of the day, she starts questioning her feelings for her fiancé and questioning her feelings for Jason.

TVGuide.com: Will we meet the fiancé?
Loughlin: You will. And that presents a great little plot, too, a great little twist.

TVGuide.com: How do you think In Case of Emergency will set itself apart from other sitcoms?
Loughlin: You don't see a lot of slapstick comedy on television, and we take the comedy and elevate it to a whole other place. I haven't seen too many shows that are that quickly paced. We're not afraid to go and be balls-out crazy. I think that is the difference.

TVGuide.com: Do you know who your "in case of emergency, call... " people are?
Loughlin: I, of course, have my husband, who's an avid golfer. I always think to myself, "Do I really want to put him [on that list], because chances are he's going to be playing 18 holes, and they're not going to be able to get a hold of him!" [Laughs]

TVGuide.com: I have to tell you, I miss Summerland!
Loughlin: Ohhh, I miss Summerland, too. I think that Summerland had a real opportunity to be a successful show, and unfortunately, we got caught in the changing of the guard. One [WB network] president that we were developed under was fired and another one was brought in, and we were too much of a baby show. We just didn't have our roots in the ground firmly enough, so it was very easy for this new president to uproot us. He didn't take what was started and nurture it. Instead, he basically gave us no food and water.

TVGuide.com: I loved that role for you, and it was a great cast, as well.
Loughlin: We had an awesome cast and that show was near and dear to my heart, because I was one of the creators, so I will always love it. It makes me feel good when people say they miss it, because I do think it had a great deal of potential. It was just in the wrong hands, unfortunately.

TVGuide.com: Have you watched John Stamos on ER? He's steaming up the screen!
Loughlin: He's fantastic! I just traded e-mails with him. He's in Canada right now doing a TV-movie for ABC. He's doing really well. He's got some small part in a Matthew Broderick film.

TVGuide.com: I think we should have a reunion of Aunt Becky and Uncle Jesse, in a hospital!
Loughlin: Isn't that funny? You know what's too bad — when his show Jake in Progress was on last year, I went and did an episode. But then ABC pulled the show, and it never got to air. But we thought it would have been so much fun for all the Full House fans to see it; it was so good.

TVGuide.com: I'm sure people are hoping we'll get to see you two in an episode of some show one day.
Loughlin: Yeah, I wish that [Jake in Progress] would have aired, but I do think he's doing a great job on ER. He's really come into his own. He's always been a talented actor and a good-looking guy, but with his maturity, his work has gotten better, his look has gotten better.... It's really his time to shine.

TVGuide.com: Well, hopefully for you, too. I hope In Case of Emergency does well.
Loughlin: Thank you so much! Thank you for helping us put the word out there.

Catch up with the star of another hit 1980s series, Moonlighting's Cybill Shepherd, in the Jan. 15 issue of TV Guide.

Send your comments on this Q&A to online_insider@tvguide.com