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Modern Family led the 18th annual Screen Actors Guild nominations Thursday with five mentions, as the sitcom's cast will look to defend its comedy ensemble crown.

The show will vie for ensemble honors against Glee, The Office, 30 Rock and The Big Bang Theory, which broke into the category for the first time.

Four Modern Family cast members — Sofia Vergara and Emmy winners Julie Bowen, Ty Burrell and Eric Stonestreet — picked up acting nominations.

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Vergara and Bowen are up against three-time champ Tina Fey (30 Rock), defending champ Betty White (Hot in Cleveland) and Edie Falco (Nurse Jackie). Burrell and Stonestreet's competition include Steve Carell (The Office), Jon Cryer (Two and a Half Men) and Alec Baldwin (30 Rock), who will go for an unprecedented six-peat in the comedy actor race.

In drama, two-time reigning champ Julianna Margulies (The Good Wife) — already SAG's winningest performer with eight trophies — will try to defend her drama actress title against Glenn Close (Damages), Kathy Bates (Harry's Law), Jessica Lange (American Horror Story) and Kyra Sedgwick (The Closer).

The drama actor category pits reigning champ Steve Buscemi (Boardwalk Empire) against Bryan Cranston (Breaking Bad), Kyle Chandler (Friday Night Lights), Michael C. Hall (Dexter) and, in a surprise, Patrick J. Adams (Suits).

Boardwalk's ensemble will go for a repeat win against the casts of Breaking Bad, Game of Thrones, Dexter and The Good Wife.

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In film, The Help scored four nominations, including in ensemble nod, where it will face off against the casts of  The Artist, Bridesmaids, The Descendants and Midnight in Paris.The 18th annual Screen Actors Guild Awards will air live Sunday, Jan. 29 at 8/7c on TNT and TBS.

Check out the nominees below.TELEVISION
Drama Ensemble
Boardwalk EmpireBreaking Bad
Dexter
Game of Thrones
The Good WifeComedy Ensemble
The Big Bang Theory
Glee
Modern FamilyThe Office30 Rock
Actor — Drama
Patrick J. Adams, Suits
Steve Buscemi, Boardwalk EmpireKyle Chandler, Friday Night LightsBryan Cranston, Breaking BadMichael C. Hall, Dexter
Actress — Drama
Kathy Bates, Harry's LawGlenn Close, Damages
Jessica Lange, American Horror StoryJulianna Margulies, The Good Wife
Kyra Sedgwick, The Closer

Actor — Comedy

Alec Baldwin
, 30 Rock
Ty Burrell, Modern FamilySteve Carell, The Office
Jon Cryer, Two and a Half Men
Eric Stonestreet, Modern FamilyActress  — Comedy Julie Bowen, Modern FamilyEdie Falco, Nurse JackieTina Fey, 30 RockSofia Vergara, Modern FamilyBetty White, Hot in Cleveland

Actor — Miniseries or TV Movie
Laurence Fishburne, ThurgoodPaul Giamatti, Too Big to FailGreg Kinnear, The KennedysGuy Pearce, Mildred PierceJames Woods, Too Big to FailActress — Miniseries or TV Movie
Diane Lane, Cinema VeriteMaggie Smith, Downton Abbey
Emily Watson, Appropriate AdultBetty White, Hallmark Hall of Fame: The Lost ValentineKate Winslet, Mildred Pierce
FILM
Ensemble
The ArtistBridesmaidsThe DescendantsThe Help
Midnight in Paris
Lead Actor
Demian Bichir, A Better LifeGeorge Clooney, The Descendants
Leonardo DiCaprio, J. EdgarJean Dujardin, The ArtistBrad Pitt, Moneyball
Lead Actress
Glenn Close, Albert NobbsViola Davis, The HelpMeryl Streep, The Iron LadyTilda Swinton, We Need to Talk About KevinMichelle Williams, My Week with Marilyn
Supporting ActorKenneth Branagh, My Week with MarilynArmie Hammer, J. Edgar
Jonah Hill, MoneyballNick Nolte, Warrior
Christopher Plummer, BeginnersSupporting ActressBérénice Bejo, The Artist
Jessica Chastain, The HelpMelissa McCarthy, Bridesmaids
Janet McTeer, Albert NobbsOctavia Spencer, The Help