John Stamos and Matthew Morrison
This won't hurt a bit, Mr. Schuester. Actually, it might — a lot. But it's Will's heart, not his teeth, that is most in jeopardy when John Stamos joins Glee in Season 2's second episode as Emma's dentist beau, Dr. Carl Howell.
Fall Preview: Get scoop on your favorite returning shows
"Just when Will thinks he'll win Emma because he can sing and dance, we find out Carl used to be in an '80s boy band," reveals John, who'll likely sport a mullet for flashbacks. "I discover Will's chewing his teeth, so the other day I had, like, four fingers in Matthew Morrison's mouth."
Carl will also be administering anesthesia to hygienically challenged students Rachel, Artie, Brittany and Santana, inspiring a dreamy sequence that will take them into the world of Britney Spears...
Ellen Pompeo and Patrick Dempsey
After a miscarriage, a near fatal gunshot wound and other heart-stopping moments in the Season 6 finale of Grey's Anatomy, it stands to reason that Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) may be journeying uphill in their relationship when the medical drama returns.
Grey's Anatomy: Find out who's walking down the aisle
When we catch up with the doctors of Seattle Grace, the series has jumped ahead in time. However, Meredith hasn't clued Derek in on her miscarriage in the aftermath of the shooting rampage at the hospital.
"I know she's been avoiding telling Derek about that miscarriage, but...