24 of 24Dr. Amber Volakis (Anne Dudek), House
How She Died: Multiple organ failure caused by amantadine poisoning
Why Her Death Is Heartbreaking: Because of a combination of guilty conscience, drugs and a concussion, Dr. House fails to diagnose Amber in time to be treated. It's a particularly tragic death because House felt like he let down his best friend Dr. Wilson, who was dating Amber and had to pull the plug on her bypass and watch her die.
Photo By: Adam Taylor/Fox/Everett Collection