Miss Pettigrew Lives for a Day - If you're sick of doom and gloom, this one's for you! Amy Adams must decide between suitors, including Pushing Daisies' Lee Pace as a pianist with a dazzling romantic side. (March 7)

Leatherheads - When choosing a costar, George Clooney drafted John Krasinski from NBC's The Office. The movie pits Clooney's aging footballer against Krasinski's golden boy for Renee Zellweger's affections. (April 4)

Street Kings - House's Hugh Laurie gets to ditch the cane and the limp for a role in this highly anticipated cop thriller. Laurie hones his mean streak by playing a captain investigating police corruption. (April 11)

Forgetting Sarah Marshall - You know the guy in paparazzi photos who's awkwardly holding the celeb's purse How I Met Your Mother's Jason Segel is that guy, until his TV-star girl (Heroes' Kristen Bell) dumps him. (April 18)

Baby Mama - 30 Rock's Tina Fey is a single businesswoman who wants a baby. When she can't conceive, Amy Poehler's working girl from the wilds of South Philly agrees to act as her unlikely surrogate. And move in. (April 25)

Made of Honor - Grey's Anatomy heartthrob Patrick Dempsey stars as a bachelor whose world falls apart when his female best friend (who he's falling for) asks him to be her unconventional maid of honor. (May 2)

Speed Racer - After many delays, this live-action take on the animated series finally hits the gas. To protect his family's business, Speed joins forces with Lost's Matthew Fox in a deadly cross-country race. (May 9)

Mister Foe - This indie flick will be notable for the appearance of Moonlight's Sophia Myles. Myles plays a fetching hotel worker who becomes the obsession of a teen who says she looks like his dead mother. (Late May)

Get Smart - The Office's Steve Carell as addled secret agent Maxwell Smart is this summer's surest thing. Partnered with the lovely Agent 99 (Anne Hathaway), he stops the bad guys with just a few wacky gadgets. (June 20)

Sisterhood of the Traveling Pants 2 - America Ferrera (Ugly Betty) and Blake Lively (Gossip Girl) rejoin Amber Tamblyn and Alexis Bledel for this sequel, which finds the quartet in college. (August 8)