25. Snickers - "You're Not You When You're Hungry" (2010)
Betty White's remarkable relevance in her ninth decade of life is due to this commercial. This ad's viral popularity led to her hosting Saturday Night Live, which won her an Emmy. And the Snickers campaign itself is still going strong seven years later.
Photo Credits: Valery Sharifulin\TASS via Getty Images; DANIEL POWER, DANIEL POWER/THE CW; getty; update; Cliff Lipson/CBS; Kevin Mazur, Getty Images for NARAS; John Shearer, Getty Images; Jamie McCarthy, Getty Images; Matt Dinerstein/SHOWTIME; Jeff Kravitz/Getty Images; Ben Leuner / AMC; Alberto E. Rodriguez/Getty Images