Don't let her innocent face fool you. Nancy Botwin (Mary-Louise Parker) makes ends meet for her three sons and brother-in-law by trafficking large amounts of drugs. Her latest gambit: She married and had a kid with Tijuana's mayor and drug lord, Esteban Reyes. Watch a six-night marathon of the award-winning, premium-TV comedy Weeds on TV Guide Network from Sunday, Oct. 17, to Friday, Oct. 22, 9 p.m.-2 a.m. ET/PT.

Dick Whitman was born to a prostitute and one of her clients, Archibald Whitman. During the war, he stole the identity of a fellow soldier who died in action and became advertising big shot Don Draper. Those who learn about his inauspicious past sometimes find themselves cut out of his present.

Jackie Peyton (Edie Falco) is a no-nonsense nurse who relies on more than coffee and cigarettes to get through crazy shifts at the hospital. She pops or snorts whatever prescription medications on which she can lay her hands. She also has a husband and two daughters about whom almost none of her co-workers know. Unfortunately, her former lover, Eddie, who's also the hospital pharmacist (convenient!), is now in the know.

When struggling high school chemistry teacher Walter White (Bryan Cranston) is diagnosed with terminal cancer, he turns to cooking crystal meth with a former student in order to secure his family's financial future. Thus begins a double life he has to carry out right under the nose of his DEA agent brother-in-law.

Desperate Housewives loves a good secret-life story line, and the big Season 6 mystery centers on new neighbor Angie Bolen (Drea de Matteo) and her family. She's not only running from the police, but also from her very dangerous ex-lover (and son's father) Patrick Logan, who now knows she's living on Wisteria Lane. Uh-oh.

Hannah Baxter (Billie Piper) may seem like the girl next door, but she's actually a call girl next door who goes by the pseudonym "Belle De Jour." Though she tries to keep her two lives separate, they have a way of overlapping when she lets down her guard.

Growing up is hard enough when you're not trying to conceal superpowers. Smallville's Clark Kent (Tom Welling) has to deal with grades, girls, and kryptonite.

Okay, so Amy Juergens (Shailene Woodley) didn't have much of a secret life once her pregnancy became public. But here's the deal: You call your show Secret Life, you get a place in our Secret Lives gallery.

Blood spatter analyst Dexter Morgan (Michael C. Hall) also happens to be a vigilante serial killer. The suburban dad manages to keep up his facade not only for the entire police force, but also his detective sister. Of course, the merging of real and secret lives can be disastrous – as Dex learned when one of his targets killed his wife in Season 5.

Bill Henrickson (Bill Paxton) planned to be a one-woman man when he married Barbara, but he soon wound up with two more wives, Nicolette and Margene, and a boatload of children. The family's three adjacent houses helped keep the arrangement secret —until Barb outed the family to some nosy neighbors in Season 2, and Bill himself went public after winning a Utah state Senate seat in Season 4. What's next? They're planning to get one big place together.

Family patriarch William Walker (Tom Skerritt) must be glad to be dead. His widow and five adult children would surely kill him if he wasn't. Among Papa Walker's numerous transgressions, they've discovered shady business deals, multiple affairs, even a secret love child.

Chuck Bartowski (Zachary Levi) is an underachieving computer whiz who works in a dead-end job at the local Buy More. But his life undergoes a massive overhaul when the world's greatest spy secrets are inadvertently uploaded to his brain. Now he must use his flashes of information to help the government thwart assassins and international terrorists — and try to keep it all secret from his family and friends.

Yes, Sue Sylvester (Jane Lynch) can be one cruel woman, but the Cheerios coach harbors a secret softer side. Will becomes suspicious after Sue allows Becky, a student with Down syndrome, onto her squad, and donates money to build wheelchair ramps in the school. But we soon learn, in an eye-opening scene, that Sue has an older sister with Down syndrome.