Although he got his start acting in commercials at the age of 2, Walker's first notable starring role was on the 1986 syndicated sitcom Throb. He played Jeremy Beatty, the son of a thirtysomething divorcee who lands a job at a small record label. He was later replaced by Sean de Veritch after the first season.

Walker guest-starred on the CBS soap opera as Brandon Collins, an employee of Eric Braeden's Victor Newman. Although Victor set Brandon up with his daughter, she was secretly dating another of Newman Enterprises employee.

After starring in the critically panned surfer-buddy comedy Meet the Deedles, Walker found success in this 1998 dramedy. Walker played good-guy basketball star Skip Martin, whom Jennifer (Reese Witherspoon) corrupts when she and her brother David (Tobey Maguire) find themselves trapped in a 1950s sitcom.

In this 1999 small-town football drama, Walker played Lance Harbor, the star quarterback who is injured and replaced by Jonathan Moxon (James Van Der Beek).

Walker continued his streak of playing handsome high schoolers in this 1999 modern adaptation of Pygmalion. Walker played Dean Sampson, Jr., who bets his best friend Zack (Freddie Prinze, Jr.) that he can't turn geek Laney (Rachael Leigh Cook) into the next prom queen.

In this 2000 thriller, Walker played Caleb Mandrake, a member of a elite secret fraternity who accidentally kills the best friend of his fraternity brother Luke McNamara (Joshua Jackson).

In the first film of the franchise that what would launch his career-defining role, Walker played undercover cop Brian O'Conner, who infiltrates a local racing crew run by Dominic Toretto (Vin Diesel) in order to find out who is stealing semi-trailer rucks.

In this 2001 horror flick, Walker played Lewis Thomas, a college student who, in a bid to get his childhood friend (Leelee Sobieski) to like him, offers to drive her home from her university. The road trip ends in disaster after Lewis and his brother (Steve Zahn) pull a CB radio prank on a truck driver who then tries to murder them.

In the 2003 sequel, Walker reprised his role as now ex-cop Brian O'Conner, who helps U.S. Customs infiltrate an Argentine drug cartel with the assistance of his former friend Roman (Tyrese Gibson).

This 2003 adaptation of a Michael Crichton novel starred Walker as Chris Johnston, the son of a professor who travels back to France in 1357 to save his father.

Walker starred opposite Jessica Alba in this 2005 action drama. He played Jared, a man who, after losing his job, discovers a sunken ship full of cocaine and finds disastrous results when he tries to turn a profit.

Walker starred in this 2006 action-adventure drama as Jerry Shepard, a guide at an Antarctica research base who must rely on his pack of sled dogs after he gets trapped in a heavy snowstorm while transporting a professor to a nearby mountain to find a rare meteorite.

Walker starred in this 2006 crime film as a low-level mafioso who is tasked by his crime boss with disposing of a gun that killed three corrupt cops. When the murder weapon falls into the hands of Russian mob, he must work to get it back and save his life.

In this critically acclaimed 2006 Clint Eastwood film, Walker played Sergeant Hank Hansen, who helped with the first flag raising over Iwo Jima.

Following the somewhat lackluster The Fast and the Furious: Tokyo Drift — the only Fast film in which Walker did not appear — the fourth movie in the franchise saw Walker reprise his role as now-FBI Agent Brian O'Conner, who crosses paths again with Dom (Vin Diesel) while trying to track down drug dealer Arturo Braga (John Ortiz).

Walker starred in this 2010 crime drama as John, a member of a crew of bank robbers trying to pull off a large-scale heist that goes awry.

Once again, Walker reprised his role as now former FBI agent-turned-criminal Brian O'Conner, who helps break Dom out of prison to pull off a score in Rio de Janeiro, where they are hunted down by DSS agent Luke Hobbs (Dwayne Johnson).

Following the Rio heist, Walker's Brian O'Conner must help Dom (Vin Diesel) assist DSS Agent Luke Hobbs (Dwayne Johnson) take down a former British Special Forces soldier who has essentially brainwashed a presumed-dead Letty (Michelle Rodriguez) into doing his dirty work.

Set to be released on December 13, the film stars Walker as Nolan, the father of a newborn who must keep his daughter alive when a hurricane floods the hospital and causes failures in the power supply.