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Check out exclusive photos from the season premiere
1 of 10 Bob D'Amico/ABC
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Grey's Anatomy will launch its 10th season with a two-hour premiere on Thursday, Sept. 26 at 9/8c and TVGuide.com has the exclusive first look.
2 of 10 Richard Cartwright/ABC
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Grey Sloan Memorial will be inundated with new patients when a giant mudslide in Seattle injures a group of first responders and citizens.
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But what about Jackson, who was in the bus explosion in the Season 9 finale?
4 of 10 Richard Cartwright/ABC
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Jackson will have his hands full when both April and Stephanie want to take care of him — after April gave him an ultimatum.
5 of 10 Richard Cartwright/ABC
Could this be the end for Mousey, who was seen hitting her head in the new promo for Season 10?
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How will Owen handle a shorthanded ER in the wake of the storm?
7 of 10 Richard Cartwright/ABC
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Callie and Arizona, who cheated with Dr. Boswell in the finale, will be forced to work together. In the second hour, Callie will make a bold decision regarding their relationship.
8 of 10 Richard Cartwright/ABC
Alien's Veronica Cartwright will guest-star in the premiere as a victim of the mudslide.
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In the second hour, the doctors will come together upon receiving devastating news.
10 of 10 Richard Cartwright/ABC