Alexandra, Jane, and Sukie (Cher, Susan Sarandon, and Michelle Pfeiffer), The Witches of Eastwick
Unlike most of the witches on this list, these three suburban women weren't aware of their powers until a mysterious (devilish) man (Jack Nicholson) comes to town and "arouses" their magic. When their newfound powers make them outcasts, they take out naysayers. (In one memorable scene, a woman they have cursed vomits cherry stones until her confused husband beats her to death with a fire poker!) But these witches' most troubling curse? The awful (and, thankfully, short-lived) TV adaptation on ABC.